Posts Tagged cocrystalization

New publication: “Real-time monitoring of cocrystallization processes by solvent evaporation : a near infrared study”

  • Mafalda C. Sarraguça, Maria Paisana, João Pinto, João A. Lopes, “Real-time monitoring of cocrystallization processes by solvent evaporation : a near infrared study”,  Eur. J. Pharm. Sci., 90, 76 -84 (2016) doi:10.1016/j.ejps.2015.12.025.Imagem1

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New paper: “Batch Statistical Process Monitoring Approach to a Cocrystallization Process”

  • Mafalda C. Sarraguça, Paulo R. S. Ribeiro, Adenilson O. Dos Santos, João A. Lopes, “Batch Statistical Process Monitoring Approach to a Cocrystallization Process”, J. of Pharm. Sci., 104, 4099–4108 (2015).Sem Título

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III SIMPÓSIO DO NUPFARQ – Universidade do Maranhão Brazil

The III Simpósio do NUPFRAQ will be enclosed in the National Week of Science and Technology ( Semana Nacional de Ciência e Tecnologia de 2015, (SNCT 2015)) and will be held at Universidade Federal do Maranhão, Imperatriz, Brazil between 04 and 06 of November.

Mafalda Sarraguça will present a conference entitled: “Vibrational spectroscopy applied to the synthesis and characterization of pharmaceutical cocrystals with industrial relevance”,  and João  Lopes will have a talk entitled “The current state of process analytics for real-time characterization of in-process materials adoption by the pharmaceutical industry”.

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Mafalda Sarraguça presentation entitled ” Furosemide and p-aminobenzoic acid cocrystals. A near infrared spectroscopy study.” at SPQ in Coimbra, Portugal.


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Presentation of Mafalda Sarraguça at EuPAT 7, Graz, Austria

Mafalda Sarraguça presentation entitled ” Near infrared spectroscopy as a PAT tool to monitor cocrystallizations” at EuPAT7  in Austria.


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Call for PhD Studentships – University of Porto

Title: Quality-by-design (QbD) based process development of cocrystals for modified-release drug delivery

Scientific supervision: The PhD program will be supervised by Dr. João Almeida Lopes (Faculty of Pharmacy, University. of Lisbon, Lisbon, Portugal) and by Dr. Mafalda Sarraguça (REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal)

Description: The pharmaceutical factories of the future will rely mostly on these technologies since drugs like biopharmaceuticals will increase their share, thus opening the way to stratified medicines and personalized medicine. This paradigm shift will require a new generation of pharmacists with competences in process design, monitoring and control that can cope with an increasing demand of new products to be manufactured in small batch sizes, eventually using manufacturing concepts relatively new such as continuous manufacturing. Pharmaceutical cocrystals are interesting to the pharmaceutical industry since they offer a number of opportunities to modify the chemical and/or physical properties of an API without changing its structure, and are a potential alternative in the selection of optimal solid forms in drug development. The ability to control cocrystallization on-line represents a highly useful process which aligns well with the current regulatory drive towards continuous monitoring and real-time quality-control. A sound cocrystallization process is the key to ensure that the final product is consistent delivered with the intend characteristics. This objective can be accomplished by applying the concepts of quality-by-design (QbD) to the cocrystallization process. By using PAT tools such as near infrared spectroscopy (NIR) and Raman spectroscopy the process can be monitored on-line and in real-time with the objective of controlling the cocrystallization process through timely measurements of the critical quality performance attributes such as solvent content and seeding time and in this way ensuring the cocrystals quality. This project is intended to accelerate the development of new pharmaceutical forms based on co-crystals for modified release drug delivery. Manufacturing and testing of designed co-crystals require a significant amount of time and analytical resources that can be circumvented by the adoption of PAT tools. These tools will integrate the design, manufacturing and characterization of the cocrystals acting as an unified methodology for design, production and testing. PAT tools such as vibrational spectroscopic tools (NIR and Raman spectroscopy) and concepts of QbD will be developed and applied and in this way gain in-depth process understanding, to mitigate risk of delivering cocrystals with poor quality.

Application requirements: Master or BSc in Chemistry, Chemical Engineering , Pharmaceutical sciences or related areas with a minimal classification of 15. The selected candidate will apply for a PhD grant in Portugal (FCT/MCTES).
Dead-line application: Applicants should send a motivation letter and Curriculum Vitae to the email address or to until 4 of May.

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Mafalda Sarraguça presentation at PSSRC 2014 in Slovenia.

Mafalda Sarraguça presentation entitled ” Near infrared spectroscopy as a PAT tool to monitor on-line cocrystallizations” at PSSRC 2014 in Slovenia.

PSSRC2014 slovenia

PSSRC2014 Slovenia

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overall unit publication digest // (Jan-Oct 2014)


Pharmaceuticals / PAT

  • R. Matias, P.R.S. Ribeiro, M.C. Sarraguça, J.A. Lopes* (2014) A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests, Anal. Met., 6(9), 3065-3071 [doi:10.1039/C3AY41874J].
  • Mafalda C. Sarraguça, Paulo R. Ribeiro, Adenilson Santos, Marta C. Silva, João A. Lopes* (2014) A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy, Int. J. Pharmaceut., 471, 478-484 [doi:10.1016/j.ijpharm.2014.06.003]
  • Ricardo N.M.J. Páscoa, Mafalda C. Sarraguça, Luis M. Magalhães, João R. Santos, António O.S.S. Rangel, João A. Lopes. Chapter 103: Use of near infrared spectroscopy for coffee beans quality assessment, pag. 933-942. In: Coffee in Health and Disease Prevention, Section 4 – Analysis and Methods. Edited by Victor R. Preedy, Academic Press, Elsevier, London, UK 2014 (ISBN: 978-0-12-409517-5); [link]



  • Sousa C, Botelho J, Silva L, Grosso F, Nemec A, Lopes JA, Peixe L*, MALDI-TOF MS and chemometric based identification of Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. International Journal of Medical Microbiology [doi:10.1016/j.ijmm.2014.04.014]
  • Ângela Novais, Clara Sousa, Juan de Caballero, Ana Fernandez-Olmos, João Lopes, Maria Helena Ramos, Teresa M Coque, Rafael Cantón, Luísa Peixe, MALDI-TOF mass spectrometry as a tool for discrimination of high-risk Escherichia coli clones from phylogenetic groups B2 (ST131) and D (ST69, ST405, ST393), European Journal of Clinical Microbiology & Infectious Diseases [doi: 10.1007/s10096-014-2071-5]
  • Sousa C, Silva L, Grosso F, Nemec A, Lopes J, Peixe L. Discrimination of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex species by Fourier Transform Infrared Spectroscopy, European Journal of Clinical Microbiology and Infectious Diseases [doi: 10.1007/s10096-014-2078-y]
  • Sousa CCS, Grosso F, Meirinhos-Soares L, Peixe L, Lopes JA* (2014) Identification of carbapenem-resistant A. baumannii clones using infrared spectroscopy, J. Biophotonics, 7(5), 287–294 [doi: 10.1002/jbio.201200075]
  • R.G. Saraiva, J.A. Lopes, J. Machado, P. Gameiro, M.J. Feio* (2014) A novel approach to discriminate E. coli based on its porin expression profile: comparison between ATR and transmission mode FTIR spectroscopy, J. Biophotonics, 7(6), 392-400 [doi: 10.1002/jbio.201200131]
  • Clara Sousa, Liliana Silva, Filipa Grosso, João P. Lopes, Luísa Peixe* (2014) Development of a FTIR-ATR based model for typing clinically relevant Acinetobacter baumannii clones belonging to ST98, ST103, ST208 and ST218, Journal of Photochemistry and Photobiology B: Biology, 133, 108-114 [doi:10.1016/j.jphotobiol.2014.02.015]
  • Clara C. Sousa and João A. Lopes. Chapter 20: Infrared spectroscopy detection coupled to chemometrics to characterize foodborne pathogens at a subspecies level, page 385. In: Mathematical and Statistical Approaches in Food Science and Technology. Edited by Daniel Granato and Gáston Ares,IFT Press – Wiley-Blackwell.UK. 2014. (ISBN: 978-1-118-43368-3); [link]


Cultural heritage

  • Sílvia Mas, Catarina Miguel, Maria João Melo, João A. Lopes, Anna de Juan (2014) Screening and quantification of proteinaceous binders in medieval paints based on micro-Fourier transform infrared spectroscopy and multivariate curve resolution alternating least squares, Chemom. Intell. Lab Syst., 134, 148-147 [doi:10.1016/j.chemolab.2014.03.012]



  • Couto M.C.M., Pinto I., Madureira T.V., Rocha M.J., Tiritan M.E., Lopes J.A. and Almeida A.A. (2014), Lower Douro river basin (Portugal) water quality – Focus on trace element changes and anthropogenic sources of contamination, Global NEST Journal,16(2), 251-267


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