Posts Tagged chemometrics

New publication: “Real-time monitoring of cocrystallization processes by solvent evaporation : a near infrared study”

  • Mafalda C. Sarraguça, Maria Paisana, João Pinto, João A. Lopes, “Real-time monitoring of cocrystallization processes by solvent evaporation : a near infrared study”,  Eur. J. Pharm. Sci., 90, 76 -84 (2016) doi:10.1016/j.ejps.2015.12.025.Imagem1
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Call for PhD Studentships – University of Porto/Lisboa

Candidates for PhD Programs

Description: The research centers REQUIMTE and iMed.ULisboa are seeking for candidates to PhD grants to develop a research work under the listed scientific research topics (one candidate for topic). It is expected that candidates be highly motivated to pursue a four-year PhD working plan.  The candidates are expected to conduct their main research activities at the host institution (see below) but it is expected that they might spend short periods in other locations together with our research partners in order to consolidate their work and scientific skills (see below). All topics involve the strong development of skills in chemometrics (multivariate data analysis), quality-by-design (QbD) and process analytical technology (PAT) concepts and have an industrial orientation (involving working with industrial partners).

Topics:

A) “High-throughput monitoring, process optimization and characterization of functionalized polymeric nanoparticles for cancer therapy”

Host Institution: Faculty of Pharmacy, University of Lisbon, Partners location: Austin/USA, Tel Aviv/Israe

B) “Synthesis and characterization of pharmaceutical cocrystals/Formulation of cocrystals-based drug products for modified-release drug delivery”

Host Institution: Faculty of Pharmacy, University of Porto, Partners location: Lisbon, Imperatriz/Brazil

C) “Modelling and monitoring of systems for the continuous production of drug products towards real-time release testing”

Host Institution: Faculty of Pharmacy, University of Lisbon, Partners location: Porto, Kuopio/Finland, Ghent/Belgium

Scientific supervision: The PhD programs will be supervised by Dr. João Almeida Lopes (iMed.ULIsboa, Faculty of Pharmacy, University. of Lisbon, Lisbon, Portugal) and by Dr. Mafalda Sarraguça (REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal)

Requirements: BSc+Master in Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biochemistry or related areas with a minimal overall classification of 15. The selected candidates will apply for a PhD grant in Portugal (FCT/MCTES) in July 2016.

Application dead-line: Applicants should send a short motivation letter (one paragraph) and Curriculum Vitae to jlopes@ff.ulisboa.pt until the 15th of June 2016. Please include in your letter the topic of your major interest (A, B or C).

 

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new publication:A FT-NIR spectroscopy methodology for estimating the firing distance based on the direct analysis of the bullet impact surface

A new paper from our group has been published in Analyst with the title :”A FT-NIR spectroscopy methodology for estimating the firing distance based on the direct analysis of the bullet impact surface”, by Jorge Sarraguca, Catarina Lima, Filipe Machado, Joao Lopes, Agostinho A Almeida, Luis Fernandes, Teresa Magalhães and Agostinho Santos.

DOI: 10.1039/C6AN00247A

Please follow the link below:
http://pubs.rsc.org/en/content/articlelanding/2014/AN/C6AN00247A#!divAbstract

 

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New paper: “Batch Statistical Process Monitoring Approach to a Cocrystallization Process”

  • Mafalda C. Sarraguça, Paulo R. S. Ribeiro, Adenilson O. Dos Santos, João A. Lopes, “Batch Statistical Process Monitoring Approach to a Cocrystallization Process”, J. of Pharm. Sci., 104, 4099–4108 (2015).Sem Título

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III SIMPÓSIO DO NUPFARQ – Universidade do Maranhão Brazil

The III Simpósio do NUPFRAQ will be enclosed in the National Week of Science and Technology ( Semana Nacional de Ciência e Tecnologia de 2015, (SNCT 2015)) and will be held at Universidade Federal do Maranhão, Imperatriz, Brazil between 04 and 06 of November. http://nupfarq.wix.com/iiisimposioImagem1

Mafalda Sarraguça will present a conference entitled: “Vibrational spectroscopy applied to the synthesis and characterization of pharmaceutical cocrystals with industrial relevance”,  and João  Lopes will have a talk entitled “The current state of process analytics for real-time characterization of in-process materials adoption by the pharmaceutical industry”.

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Mafalda Sarraguça presentation entitled ” Furosemide and p-aminobenzoic acid cocrystals. A near infrared spectroscopy study.” at SPQ in Coimbra, Portugal.

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Presentation of Mafalda Sarraguça at EuPAT 7, Graz, Austria

Mafalda Sarraguça presentation entitled ” Near infrared spectroscopy as a PAT tool to monitor cocrystallizations” at EuPAT7  in Austria.

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Call for PhD Studentships – University of Porto

Title: Quality-by-design (QbD) based process development of cocrystals for modified-release drug delivery

Scientific supervision: The PhD program will be supervised by Dr. João Almeida Lopes (Faculty of Pharmacy, University. of Lisbon, Lisbon, Portugal) and by Dr. Mafalda Sarraguça (REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal)

Description: The pharmaceutical factories of the future will rely mostly on these technologies since drugs like biopharmaceuticals will increase their share, thus opening the way to stratified medicines and personalized medicine. This paradigm shift will require a new generation of pharmacists with competences in process design, monitoring and control that can cope with an increasing demand of new products to be manufactured in small batch sizes, eventually using manufacturing concepts relatively new such as continuous manufacturing. Pharmaceutical cocrystals are interesting to the pharmaceutical industry since they offer a number of opportunities to modify the chemical and/or physical properties of an API without changing its structure, and are a potential alternative in the selection of optimal solid forms in drug development. The ability to control cocrystallization on-line represents a highly useful process which aligns well with the current regulatory drive towards continuous monitoring and real-time quality-control. A sound cocrystallization process is the key to ensure that the final product is consistent delivered with the intend characteristics. This objective can be accomplished by applying the concepts of quality-by-design (QbD) to the cocrystallization process. By using PAT tools such as near infrared spectroscopy (NIR) and Raman spectroscopy the process can be monitored on-line and in real-time with the objective of controlling the cocrystallization process through timely measurements of the critical quality performance attributes such as solvent content and seeding time and in this way ensuring the cocrystals quality. This project is intended to accelerate the development of new pharmaceutical forms based on co-crystals for modified release drug delivery. Manufacturing and testing of designed co-crystals require a significant amount of time and analytical resources that can be circumvented by the adoption of PAT tools. These tools will integrate the design, manufacturing and characterization of the cocrystals acting as an unified methodology for design, production and testing. PAT tools such as vibrational spectroscopic tools (NIR and Raman spectroscopy) and concepts of QbD will be developed and applied and in this way gain in-depth process understanding, to mitigate risk of delivering cocrystals with poor quality.

Application requirements: Master or BSc in Chemistry, Chemical Engineering , Pharmaceutical sciences or related areas with a minimal classification of 15. The selected candidate will apply for a PhD grant in Portugal (FCT/MCTES).
Dead-line application: Applicants should send a motivation letter and Curriculum Vitae to the email address jjlopes@ff.ulisboa.pt or to mafalda.cruz@ff.up.pt until 4 of May.

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(new publication) “Value-adding to red grape pomace exploiting eco-friendly FT-NIR spectroscopy technique”

The article titled “Value-adding to red grape pomace exploiting eco-friendly FT-NIR spectroscopy technique” by Ricardo N.M.J. Páscoa, Sandia Machado, Luís M. Magalhães, and João A. Lopes is now published in Food. Bioprocess. Technol.

[doi:10.1007/s11947-014-1454-z]

grape

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(new publication): “Optimization of NIR spectroscopy based PLSR models for critical properties of vegetable oils used in biodiesel production”

The paper titled: “Optimization of NIR spectroscopy based PLSR models for critical
properties of vegetable oils used in biodiesel production”  by Silvana A. Moreira, Jorge Sarraguça, Daniel F. Saraiva, Renato Carvalho, and João A. Lopes is now available in Fuel (Fuel 150 (2015) 697–704).

http://dx.doi.org/10.1016/j.fuel.2015.02.082 ).

fuel page

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